Unlocking the Connection Between the Gut Microbiome, Muscle Function, and Cognition in the Elderly: Insights from the PROMOTe Trial

The interplay between our gut health and overall wellbeing has captivated the scientific community for years. In an ambitious exploration of this relationship, the PROMOTe (Promotion of Muscle function and Cognition) trial  has recently shed light on how gut microbiome modulation could influence muscle function and cognitive health in the elderly.

This study involved 36 twin pairs, aged 60 and above, who underwent a 12-week intervention involving prebiotic supplementation, resistance exercise, and branched-chain amino acid supplementation. The trial’s double-blind, placebo-controlled design ensured the reliability of its outcomes.

One of the key findings was the distinct impact of prebiotic supplementation on cognition. While muscle function parameters showed no significant difference between the prebiotic and placebo groups, cognitive measures hinted at a promising improvement among those receiving the prebiotic supplement.

These results underscore the intricate relationship between gut health and brain function. They suggest that targeting the gut microbiome could offer a novel avenue for enhancing cognitive health among the aging population.

Moreover, the trial’s success in employing a remote methodology to engage older participants highlights the feasibility of conducting comprehensive health interventions outside traditional clinical settings. This approach could democratize access to cutting-edge health strategies, making them more accessible to wider demographics.

In conclusion, the PROMOTe trial not only illuminates the potential cognitive benefits of gut microbiome modulation but also sets a precedent for future research in this realm. As we continue to unravel the complex connections between our gut health and overall wellbeing, such studies are invaluable, pointing us toward innovative strategies to support aging populations in maintaining mental acuity and vitality.



Ni Lochlainn, M., Bowyer, R.C.E., Moll, J.M. et al. Effect of gut microbiome modulation on muscle function and cognition: the PROMOTe randomised controlled trial. Nat Commun 15, 1859 (2024). https://doi.org/10.1038/s41467-024-46116-y


2 thoughts on “Unlocking the Connection Between the Gut Microbiome, Muscle Function, and Cognition in the Elderly: Insights from the PROMOTe Trial”

  1. Antonietta Berardelli


    I am having issues with my DAO enzyme (histamine reactor), and I understand that this particular enzyme is linked to kidney health. Kidney filtration depletes as the aging progresses, and subsequently the telospheres are hindered or eradication. They are biomarkers in the aging process. Is there a telosphere test that I can take, to find out my epigenetic age.

    kind Regards,
    Antonietta Berardelli

    1. David Cheishvili

      Hello Antonietta,

      Thank you for your interest. To clarify, a telomere test measures the length of telomeres, which are the protective caps at the ends of chromosomes that shorten as we age. This test provides a general indication of cellular aging.

      On the other hand, an epigenetic test, like our epiAge, uses DNA methylation analysis to determine biological age. It’s a different approach that can give a more detailed insight into how your body is aging at a molecular level.

      Since you’re interested in measuring your epigenetic age, you might consider trying our epiAge test. It’s based on DNA methylation, not telomere length. You can find more information and order the test here: https://hkgepitherapeutics.com/product/epiage/

      David Cheishvili, Chief Innovation Officer, HKG Epitherapeutics

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